HIAT2022 - Table of Session: MO3 (Monday Session 3)

Paper	Title	Page
MO3I1	Developments towards a Compact Carbon Ion Linac for Cancer Therapy	14
	B. Mustapha, D.A. Meyer, A. Nassiri, Y. Yang ANL, Lemont, Illinois, USA R.B. Agustsson, A. Araujo, S.V. Kutsaev, A.Yu. Smirnov RadiaBeam, Los Angeles, California, USA
	Funding: This work was supported by the U.S. Department of Energy, Office of Nuclear Physics, under Contract No. DE-AC02-06CH11357 and Office of High Energy Physics SBIR/STTR Award DE-SC0015717. Hadron therapy offers improved localization of the dose to the tumor and much improved sparing of healthy tissues, compared to traditional X-ray therapy. Combined proton/carbon therapy can achieve the most precise dose confinement to the tumor. Moreover, recent studies indicated that adding FLASH capability to such system may provide significant breakthrough in cancer treatment. The Advanced Compact Carbon Ion Linac (ACCIL) is a conceptual design for a compact ion linac based on high-gradient accelerating structures operating in the S-band frequency range. Thanks to this innovation, the footprint of this accelerator is only 45 m, while its capabilities are well beyond the current state of the art for hadron therapy machines and include: operation up to 1000 pulses per second, pulse to pulse energy variation to treat moving tumors in layer-by-layer regime. ACCIL is capable of accelerating all ions with mass-to-charge ratio A/q ~ 2 to a full energy of 450 MeV/u, and that includes protons, helium, carbon, oxygen and neon. With very short beam pulses of ~ 1 ’s and high instantaneous dose delivery, ACCIL is capable of delivering FLASH-like doses (>100 Gy/sec) for most ion species. In close collaboration between Argonne and Radiabeam, we have developed different design options and prototypes of the high-gradient structures needed for ACCIL. Following an overview of the ACCIL design and its capabilities, the most recent results from the high-gradient structure R&D and future plans will be presented and discussed.
	Slides MO3I1 [3.259 MB]
DOI •	reference for this paper ※ https://doi.org/10.18429/JACoW-HIAT2022-MO3I1
About •	Received ※ 27 June 2022 — Revised ※ 10 August 2022 — Accepted ※ 05 September 2022 — Issue date ※ 05 September 2022
Cite •	reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)

MO3C2	Establishment of the New Particle Therapy Research Center (PARTREC) at UMCG Groningen	20
	A. Gerbershagen, L. Barazzuol, S. Both, S. Brandenburg, R.P. Coppes, P.G. Dendooven, B.N. Jonespresenter, J.M. Schippers, E.R. Van Der Graaf, P. Van Luijk, M.-J. van Goethem PARTREC, Groningen, The Netherlands
	After 25 years of successful research in the nuclear and radiation physics domain, the KVI-CART research center in Groningen is upgraded and re-established as the PARticle Therapy REsearch Center (PARTREC). Using the superconducting cyclotron AGOR and being embedded within the University Medical Center Groningen, it operates in close collaboration with the Groningen Proton Therapy Center. PARTREC uniquely combines radiation physics, medical physics, biology and radiotherapy research with an R&D program to improve hadron therapy technology and advanced radiation therapy for cancer. A number of further upgrades, scheduled for completion in 2023, will establish a wide range of irradiation modalities, such as pencil beam scanning, shoot-through with high energy protons and SOBP for protons, helium and carbon ions. Delivery of spatial fractionation (GRID) and dose rates over 300 Gy/s (FLASH) are envisioned. In addition, PARTREC delivers a variety of ion beams and infrastructure for radiation hardness experiments conducted by scientific and commercial communities, and nuclear science research in collaboration with the Faculty of Science and Engineering of the University of Groningen.
	Slides MO3C2 [12.702 MB]
DOI •	reference for this paper ※ https://doi.org/10.18429/JACoW-HIAT2022-MO3C2
About •	Received ※ 16 June 2022 — Revised ※ 28 June 2022 — Accepted ※ 01 July 2022 — Issue date ※ 10 August 2022
Cite •	reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)

MO3I3	Heavy Ion Stripping	24
	P. Gerhard, M.T. Maier GSI, Darmstadt, Germany
	Ion stripping is primarily an essential technique for heavy ion accelerators in order to reach higher beam energies within reasonable size and budget limits. Due to the nature of the stripping process, the resulting ion beam contains ions of different charge states. Therefore, high beam loss is typically associated, making the net stripping efficiency one of the decisive elements of the overall performance of an accelerator or facility. Several technical implementations of strippers have been and are still being developed in order to obtain optimal stripping for different ions and beam energies by employing different kinds of stripping targets, namely gaseous, solid and more recently fluid materials. High beam intensities resulting in prohibitive energy deposition and target destruction are challenging. Optimizing a stripper may potentially increase the overall performance by a large factor with less effort than other actions. This gave rise to the pulsed gas stripper project at the GSI UNILAC. This talk will give an overview of different strippers at GSI and beyond. The second part will give a detailed report on the introduction of hydrogen at the GSI gas stripper.
	Slides MO3I3 [53.513 MB]
DOI •	reference for this paper ※ https://doi.org/10.18429/JACoW-HIAT2022-MO3I3
About •	Received ※ 21 June 2022 — Accepted ※ 01 July 2022 — Issue date ※ 10 August 2022
Cite •	reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)

Paper

Title

Page

Developments towards a Compact Carbon Ion Linac for Cancer Therapy

14

B. Mustapha, D.A. Meyer, A. Nassiri, Y. Yang
ANL, Lemont, Illinois, USA
R.B. Agustsson, A. Araujo, S.V. Kutsaev, A.Yu. Smirnov
RadiaBeam, Los Angeles, California, USA

Funding: This work was supported by the U.S. Department of Energy, Office of Nuclear Physics, under Contract No. DE-AC02-06CH11357 and Office of High Energy Physics SBIR/STTR Award DE-SC0015717.
Hadron therapy offers improved localization of the dose to the tumor and much improved sparing of healthy tissues, compared to traditional X-ray therapy. Combined proton/carbon therapy can achieve the most precise dose confinement to the tumor. Moreover, recent studies indicated that adding FLASH capability to such system may provide significant breakthrough in cancer treatment. The Advanced Compact Carbon Ion Linac (ACCIL) is a conceptual design for a compact ion linac based on high-gradient accelerating structures operating in the S-band frequency range. Thanks to this innovation, the footprint of this accelerator is only 45 m, while its capabilities are well beyond the current state of the art for hadron therapy machines and include: operation up to 1000 pulses per second, pulse to pulse energy variation to treat moving tumors in layer-by-layer regime. ACCIL is capable of accelerating all ions with mass-to-charge ratio A/q ~ 2 to a full energy of 450 MeV/u, and that includes protons, helium, carbon, oxygen and neon. With very short beam pulses of ~ 1 ’s and high instantaneous dose delivery, ACCIL is capable of delivering FLASH-like doses (>100 Gy/sec) for most ion species. In close collaboration between Argonne and Radiabeam, we have developed different design options and prototypes of the high-gradient structures needed for ACCIL. Following an overview of the ACCIL design and its capabilities, the most recent results from the high-gradient structure R&D and future plans will be presented and discussed.

Slides MO3I1 [3.259 MB]

DOI •

reference for this paper ※ https://doi.org/10.18429/JACoW-HIAT2022-MO3I1

About •

Received ※ 27 June 2022 — Revised ※ 10 August 2022 — Accepted ※ 05 September 2022 — Issue date ※ 05 September 2022

Cite •

reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)

MO3C2

Establishment of the New Particle Therapy Research Center (PARTREC) at UMCG Groningen

20

A. Gerbershagen, L. Barazzuol, S. Both, S. Brandenburg, R.P. Coppes, P.G. Dendooven, B.N. Jonespresenter, J.M. Schippers, E.R. Van Der Graaf, P. Van Luijk, M.-J. van Goethem
PARTREC, Groningen, The Netherlands

After 25 years of successful research in the nuclear and radiation physics domain, the KVI-CART research center in Groningen is upgraded and re-established as the PARticle Therapy REsearch Center (PARTREC). Using the superconducting cyclotron AGOR and being embedded within the University Medical Center Groningen, it operates in close collaboration with the Groningen Proton Therapy Center. PARTREC uniquely combines radiation physics, medical physics, biology and radiotherapy research with an R&D program to improve hadron therapy technology and advanced radiation therapy for cancer. A number of further upgrades, scheduled for completion in 2023, will establish a wide range of irradiation modalities, such as pencil beam scanning, shoot-through with high energy protons and SOBP for protons, helium and carbon ions. Delivery of spatial fractionation (GRID) and dose rates over 300 Gy/s (FLASH) are envisioned. In addition, PARTREC delivers a variety of ion beams and infrastructure for radiation hardness experiments conducted by scientific and commercial communities, and nuclear science research in collaboration with the Faculty of Science and Engineering of the University of Groningen.

Slides MO3C2 [12.702 MB]

DOI •

reference for this paper ※ https://doi.org/10.18429/JACoW-HIAT2022-MO3C2

About •

Received ※ 16 June 2022 — Revised ※ 28 June 2022 — Accepted ※ 01 July 2022 — Issue date ※ 10 August 2022

Cite •

reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)

MO3I3

Heavy Ion Stripping

24

P. Gerhard, M.T. Maier
GSI, Darmstadt, Germany

Ion stripping is primarily an essential technique for heavy ion accelerators in order to reach higher beam energies within reasonable size and budget limits. Due to the nature of the stripping process, the resulting ion beam contains ions of different charge states. Therefore, high beam loss is typically associated, making the net stripping efficiency one of the decisive elements of the overall performance of an accelerator or facility. Several technical implementations of strippers have been and are still being developed in order to obtain optimal stripping for different ions and beam energies by employing different kinds of stripping targets, namely gaseous, solid and more recently fluid materials. High beam intensities resulting in prohibitive energy deposition and target destruction are challenging. Optimizing a stripper may potentially increase the overall performance by a large factor with less effort than other actions. This gave rise to the pulsed gas stripper project at the GSI UNILAC. This talk will give an overview of different strippers at GSI and beyond. The second part will give a detailed report on the introduction of hydrogen at the GSI gas stripper.

Slides MO3I3 [53.513 MB]

DOI •

reference for this paper ※ https://doi.org/10.18429/JACoW-HIAT2022-MO3I3

About •

Received ※ 21 June 2022 — Accepted ※ 01 July 2022 — Issue date ※ 10 August 2022

Cite •

reference for this paper using ※ BibTeX, ※ LaTeX, ※ Text/Word, ※ RIS, ※ EndNote (xml)